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Genotype
likelihoods
This page
contains some videos which demonstrate how to use FamLink
and also Frequently Asked Questions.
Q: Can FamLink
account for mutations?
A: Yes, for the pre-defined
pedigrees we have implemented a slower algorithm that can handle mutations for
linked markers. Please note that mutations and genotype likelihoods cannot be
modeled simultaneously.
Q: Can FamLink
handle multiple linked markers?
A: Yes, the software can handle
virtually any number of linked markers. Please keep in mind that LD (allelic
association) is not modeled. We recommend at least 0.5 cM distance between
adjacent markers.
Q: Will FamLink
provide the possibility to handle X-chromosomal markers?
A: Yes, in future releases we will
extend the software with this option. X-chromosomal marker can be imported into
the software but are currently not used in any functions/computations.
Q: Will FamLink
provide the possibility to handle Y-chromosomal markers?
A: The software can import any
data, but Y-chromosomal data is currently only used to predict haplotypes.
Installation – Video demonstrating
how to install FamLink
Video 1 at Youtube
Video 1 in .wmv
format
Getting started – Introduction to
using FamLink demonstrating how to setup the Getting
started example and do likelihood calculations.
Installing FamLink
on some Windows7 machines may experience problems with permissions – This is a
known bug and future releases of FamLink will
hopefully contain a work-around for this issue. Video shows how to set
permissions for the FamLink software.
Video 3 at Youtube
Video 3 in .wmv
format
You may send comments to daniel.kling@rmv.se